Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments
نویسندگان
چکیده
منابع مشابه
Factorial versus multi‐arm multi‐stage designs for clinical trials with multiple treatments
When several treatments are available for evaluation in a clinical trial, different design options are available. We compare multi-arm multi-stage with factorial designs, and in particular, we will consider a 2 × 2 factorial design, where groups of patients will either take treatments A, B, both or neither. We investigate the performance and characteristics of both types of designs under differ...
متن کاملA comparison of bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials
When several experimental treatments are available for testing, multi-arm trials provide gains in efficiency over separate trials. Including interim analyses allows the investigator to effectively use the data gathered during the trial. Bayesian adaptive randomization (AR) and multi-arm multi-stage (MAMS) designs are two distinct methods that use patient outcomes to improve the efficiency and e...
متن کاملOptimal design for multi-arm multi-stage clinical trials
In early stages of drug development there is often uncertainty about the most promising among a set of different treatments. In order to ensure the best use of resources it is important to decide which, if any, of the treatments should be taken forward for further testing. Multi-arm multi-stage (MAMS) trials provide gains in efficiency over separate randomised trials of each treatment. They all...
متن کاملTreatment selection in multi-arm, multi-stage clinical trials
Adaptive designs that are based on group-sequential approaches have the benefit of being efficient as stopping boundaries can be found that lead to good operating characteristics with test decisions based solely on sufficient statistics. The drawback of these so called “pre-planned adaptive” designs is that unexpected design changes are not possible without impacting the error rates. “Flexible ...
متن کاملFlexible sequential designs for multi-arm clinical trials.
Adaptive designs that are based on group-sequential approaches have the benefit of being efficient as stopping boundaries can be found that lead to good operating characteristics with test decisions based solely on sufficient statistics. The drawback of these so called 'pre-planned adaptive' designs is that unexpected design changes are not possible without impacting the error rates. 'Flexible ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2016
ISSN: 0277-6715
DOI: 10.1002/sim.7159